TABLE 3.
Steady‐state unbound drug concentrations in liver, muscle, and blood of Class I compounds with good membrane permeability that are not efflux and uptake transporter substrates (n = 3, mean ± SD)
| Compound | C m, liver (µmol/L) | C m, muscle (µmol/L) | C m, blood (µmol/L) | K puu liver | K puu muscle |
|---|---|---|---|---|---|
| Antipyrine | 7.16 ± 1.38 | 5.89 ± 1.45 | 7.76 ± 0.68 | 0.932 ± 0.178 | 0.771 ± 0.215 |
| Lamotrigine | 0.879 ± 0.078 | 0.879 ± 0.059 | 0.700 ± 0.092 | 1.28 ± 0.25 | 1.28 ± 0.22 |
| Carbamazepine | 2.41 ± 0.94 | 2.64 ± 0.80 | 2.77 ± 1.08 | 0.913 ± 0.169 | 1.02 ± 0.27 |
| Propranolol | 0.303 ± 0.328* | 1.79 ± 0.51 | 1.07 ± 0.35 | 0.382 ± 0.277 | 1.67 ± 0.36 |
| Diltiazem | 0.0250 ± 0.0139* | 0.342 ± 0.096 | 0.184 ± 0.087 | 0.145 ± 0.085 | 1.96 ± 0.29 |
T‐test was performed for C m, liver versus C m, blood and C m, muscle versus C m, blood.
*
p < .05.