TABLE 5.
Steady‐state unbound drug concentrations in liver, muscle, and blood of Class III compounds that are uptake transporter substrates (n = 3, mean ± SD)
| Compound | C m, liver (µmol/L) | C m, muscle (µmol/L) | C m, blood (µmol/L) | K puu liver | K puu muscle |
|---|---|---|---|---|---|
| Memantine | 10.5 ± 3.0 | 14.3 ± 0.9* | 6.78 ± 1.37 | 1.56 ± 0.48 | 2.13 ± 0.25 |
| Diphenhydramine | 0.255 ± 0.094 | 1.74 ± 0.53* | 0.658 ± 0.413 | 0.514 ± 0.266 | 3.08 ± 0.94 |
| Pyrilamine | 0.0713 ± 0.0274* | 3.21 ± 0.64* | 0.556 ± 0.055 | 0.127 ± 0.033 | 5.78 ± 1.09 |
| Gabapentin | 6.80 ± 2.28 | 3.95 ± 0.68 | 3.05 ± 0.94 | 2.23 ± 0.34 | 1.39 ± 0.51 |
T‐test was performed for C m, liver versus C m, blood and C m, muscle versus C m, blood.
*
p < .05.