Table 1.

Relative impact of‘ age of onset, sex, APOE ε4, and disease duration on the density of neurofibrillary tangles in six cortical regions

NFT density	Middle frontal gyrus	Superior temporal gyrus	Primary motor cortex	Angular gyrus	CA1	Subiculum
n	70	69	66	69	69	68
R2 (full model)	0.407	0.376	0.253	0.326	0.210	0.159
Age of onset
Estimate	−4.49	−3.34	−2.98	−3.23	0.35	0.44
95% CI	−6.01 to −2.97	−4.90 to −1.77	−4.60 to −1.36	−4.71 to −1.75	−1.06 to 1.77	−2.10 to 2.98
Std estimate	−0.602	−0.448	−0.441	−0.475	0.059	0.042
P	<0.0001	<0.0001	0.0005	<0.0001	0.62	0.73
Sex
Estimate	−24.04	−48.54	−14.84	−33.62	−30.02	−52.70
95% CI	−52.54 to 4.46	−76.86 to −20.22	−45.37 to 15.68	−61.46 to −5.78	−55.84 to −4.19	−99.44 to −5.96
Std estimate	−0.332	−0.693	−0.222	−0.509	−0.529	−0.533
P	0.09	0.001	0.33	0.02	0.02	0.03
APOE ε4
Estimate	10.49	2.72	−22.41	2.24	9.98	27.86
95% CI	−17.22 to 38.19	−25.01 to 30.45	−52.02 to 7.20	−24.83 to 29.32	−15.3 to 35.26	−17.92 to 73.64
Std estimate	0.145	0.039	−0.335	0.034	0.176	0.282
P	0.45	0.85	0.14	0.87	0.43	0.23
Disease duration
Estimate	−2.07	−0.41	−1.76	−1.41	5.36	6.97
95% CI	−5.69 to 1.55	−4.00 to 3.18	−5.69 to 2.16	−4.93 to 2.12	2.08 to 8.63	0.94 to 13.00
Std estimate	−0.114	−0.024	−0.105	−0.085	0.380	0.279
P	0.26	0.82	0.37	0.43	0.002	0.02

Six separate multivariable multiple regressions were run, one for each brain region. Age of onset and disease duration are continuous variables, expressed in years; sex is coded as male versus female and APOE ε4 is coded as ε4 carrier versus non-carrier. Positive estimates represent higher NFT density in patients with older age of onset, males, APOE ε4 carriers, and in patients with longer disease duration. CA1 = corpus ammonis sector 1. Statistically significant P-values are indicated in bold.