Table 1.
Pathological parameters of studied adrenal glands
| Total | Men | Women | P-value | |
|---|---|---|---|---|
| N | 60 | 30 | 30 | |
| Age | 50 (18-86) | 50 (18-86) | 50 (25-85) | 0.94 |
| 18–30 years (n) | 10 | 5 | 5 | |
| 31–40 years (n) | 10 | 5 | 5 | |
| 41–50 years (n) | 10 | 5 | 5 | |
| 51–60 years (n) | 10 | 5 | 5 | |
| 61–70 years (n) | 10 | 5 | 5 | |
| >70 years (n) | 10 | 5 | 5 | |
| Adrenal cortex area (mm2) | 35.8 [23.4, 49.3] | 42.7 [24.1, 51.8] | 29.9 [21.2, 43.6] | 0.07 |
| Proportion of CYP11B2-expressing area (%) | 1.25 [0.82, 3.09] | 1.27 [0.67, 4.40] | 1.25 [0.88, 2.54] | 0.90 |
| Proportion of VSNL1-expressing area (%) | 13.7 [8.9, 19.0] | 11.8 [7.8, 17.9] | 14.5 [10.1, 20.8] | 0.16 |
| Proportion of HSD3B2-expressing area (%) | 56.8 [48.2, 63.3] | 56.5 [49.2, 60.6] | 57.1 [47.0, 66.2] | 0.63 |
| Proportion of CYB5A-expressing area (%) | 19.2 [9.9, 26.7] | 19.8 [9.9, 27.1] | 16.7 [9.6, 26.1] | 0.54 |
| Proportion of CYP11B1-expressing area (%) | 45.1 [40.5, 51.3] | 47.6 [44.0, 53.5] | 43.1 [38.3, 48.0] | 0.01 |
| Proportion of estimated ZF (%) | 42.9 [33.1, 49.7] | 44.0 [32.8, 48.5] | 40.5 [33.2, 52.2] | 0.87 |
| Ratio of CYP11B2 per VSNL1 expression (%) | 12.2 [5.0, 27.3] | 15.7 [5.0, 34.1] | 11.4 [5.0, 18.3] | 0.24 |
All enzymatic areas are represented as percentage of total cortical area. The estimated ZF proportion was calculated by subtracting the percentage of VSNL1-positive area from the percentage of HSD3B2-positive area. Data are shown as median and range (for age) or interquartile range (other variables). Differences between men and women were assessed with the Mann-Whitney U test.
Abbreviations: CYB5A, cytochrome b5 type A; CYP11B1, 11β-hydroxylase; CYP11B2, aldosterone synthase; HSD3B2, 3β-hydroxysteroid dehydrogenase type II; VSNL1, visinin-like 1; ZF, zona fasciculata.