Table 3.
Clinical characteristics and morning steroid concentrations in 298 adults
| Total | Men | Women | p | |
|---|---|---|---|---|
| N | 298 | 149 | 149 | |
| Age, years (range) | 57 (21-95) | 57 (21-95) | 57 (21-94) | 0.87 |
| BMI, kg/m2 | 26.1 [23.7, 30.0] | 26.4 [24.0, 30.0] | 26.0 [23.6, 30.0] | 0.84 |
| Hypertension, n (%) | 146/296 (49.3) | 77/147 (52.4) | 69/149 (46.3) | 0.30 |
| Diabetes mellitus, n (%) | 36/265 (13.6) | 17/130 (13.1) | 19/135 (14.1) | 0.81 |
| Dyslipidemia, n (%) | 164/275 (59.6) | 87/140 (62.9) | 76/135 (56.3) | 0.27 |
| Cortisol, nmol/L | 333 [269, 403] | 322 [255, 381] | 346 [276, 415] | 0.001 |
| 11dF, pmol/L | 692 [437, 1010] | 681 [453, 957] | 700 [404, 1104] | 0.67 |
| Corticosterone, nmol/L | 7 [4, 12] | 6 [4, 11] | 7 [4, 12] | 0.17 |
| DOC, pmol/L | 149 [94, 193] | 149 [85, 188] | 147 [101, 198] | 0.03 |
| 17OHP4, pmol/L | 1453 [806, 2534] | 1887 [1450, 2737] | 908 [527, 1453] | <0.0001 |
| A4, pmol/L | 1476 [1078, 2107] | 1550 [1185, 1935] | 1394 [976, 2268] | 0.16 |
Continuous variables are shown as median and range (for age) or interquartile range (all other variables). Differences between men and women were assessed with the Wilcoxon signed-rank test (for continuous variables) and the chi-squared test (for categorical variables).
Abbreviations: 11dF, 11-deoxycortisol; 17OHP4, 17-hydroxyprogesterone; A4, androstenedione; BMI, body mass index; DOC, 11-deoxycorticosterone.