Table 1.
SARS-CoV-2 specific IFNγ production by CD4+ and CD4+&CD8+ T cells measured by the QuantiFERON® assay, according to the proposed cutoffa at the different time points of the study (T0-T3), in previously COVID-19-infected (CoV2+) vs uninfected (CoV2-) individuals.
| Time point | T0 | T1 | T2 | T3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IFNγ+ T cells (IU/ml) | CD4 (IU/ml)(%) |
CD4&CD8 (IU/ml) (%) |
Totalb (IU/ml) (%) |
CD4 (IU/ml)(%) |
CD4&CD8 (IU/ml) (%) |
Totalb (IU/ml) (%) |
CD4 (IU/ml) (%) |
CD4&CD8 (IU/ml) (%) |
Totalb (IU/ml) (%) |
CD4 (IU/ml)(%) |
CD4&CD8 (IU/ml) (%) |
Totalb (IU/ml) (%) |
|
| CoV2- | <60 yrs n = 10 |
0 (0%) | 0 (0%) | 0 (0%) | 9 (90%) | 9 (90%) | 9 (90%) | 10 (100%) | 10 (100%) | 10 (100%) | 9 (90%) | 9 (90%) | 10 (100%) |
| >60 yrs n = 6 |
0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (33%) | 2 (33%) | 3 (50%) | 2 (33%) | 3 (50%) | 3 (50%) | |
| CoV2+ | <60 yrs n = 13 |
2 (15%) | 2 (15%) | 3 (23%) | 13 (100%) | 11 (85%) | 13 (100%) | 12 (92%) | 9 (69%) | 12 (92%) | 11 (85%) | 11 (85%) | 12 (92%) |
| >60 yrs n = 21 |
14 (67%) | 13 (62%) | 15 (71%) | 20 (95%) | 20 (95%) | 20 (95%) | 19 (90%) | 18 (86%) | 19 (90%) | 20 (95%) | 20 (95%) | 21 (100%) | |
| Overall n = 50 |
16 (32%) | 15 (30%) | 18 (36%) | 42 (84%) | 40 (80%) | 42 (84%) | 43 (86%) | 39 (78%) | 44 (88%) | 38 (76%) | 43 (86%) | 46 (92%) | |
a
The proposed cut-off values are 0.10 and 0.25 IU/ml IFNγ+CD4+ and IFNγ+CD4+&CD8+ T cells, respectively.
b
A total positive result was considered when at least one of the IFNγ+CD4+ or IFNγ+CD4+&CD8+ T cells was above the cut-off.