Fig. 3.

Frequency of cTfh cells and plasmablasts in children with COVID-19 and MIS-C. (a-b) Frequency of CD4+ T cells (a) and cTfh (b) analyzed by flow cytometry in healthy children (n=22), children in the acute (n=56) and convalescent (n=33) phases of infection, and MIS-C (n=23). (c-d) Frequency of CD4+ T cells (c) and cTfh (d) in children with acute COVID-19 classified according to disease severity: asymptomatic, n=7; mild, n=32; moderate, n=13; severe, n=4. (e-f) Frequency of B cells (e) and plasmablasts (f) analyzed by flow cytometry in healthy children (n=5), children in the acute (n=27) and convalescent (n=19) phases of the infection, and MIS-C (n=23). (g-h) Frequency of B cells (g) and plasmablasts (h) during acute infection in children with COVID-19 classified according to disease severity: asymptomatic, n=5; mild, n=14; moderate, n=4; severe, n=4. Dotted line depicts the median values found in healthy controls. Median and min to max of n donors are shown. P values were determined by Mann-Whitney U test: * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001. Control (white square), Acute (white circle), Convalescent (light grey circle), MIS-C (dark grey circle). Asymptomatic (lilac circle), mild (pink circle), moderate (violet circle), severe (purple circle).