Table 1.

Secretome Test Objects for Skin Application

No.	Biology Activity	Test Object	Testing	Ref
1.	Cutaneous wound	Human foreskin fibroblasts (HFFs)	In vitro	[14]
		Human immortalised keratinocytes (HaCaTs)	In vitro	[4,5]
		Human dermal microvascular endothelial cells (HDMECs)	In vitro	[14]
		Human dermal fibroblasts (HDFs)	In vitro	[8,15]
		Human endothelial cell	In vitro	[8]
		Human umbilical vein endothelial cells (HUVECs)	In vitro	[16]
		L929 Fibroblast	In vitro	[5]
		Wistar rats	In vivo	[17,18]
		C57BL/6J mice	In vivo	[19]
		Leprdb/db mice	In vivo	[20]
		Porcine models/ pigs	In vivo	[21]
		Rabbit ear	In vivo	[22]
		Female SCID Mice 8–9 weeks	In vivo	[4]
		Male volunteers	Clinic Phase 1	[23]
2.	Photoprotection	Human dermal fibroblasts (HDFs)	In vitro	[24,25]
		Normal human dermal fibroblast (NHDF)	In vitro	[26]
		Human dermal fibroblast (HFF-1)	In vitro	[27]
		Human immortalized keratinocytes (HaCaTs)	In vitro	[28]
		NIH-3T3 cell	In vitro	[29]
		Nude mice	In vivo	[24,28]
		Human Skin	Clinical test	[30]
3.	Hair Growth	Human follicle dermal papilla cells (HFDPCs)	In vitro	[31–33]
		Human epithelial keratinocytes (HEKs)	In vitro	[31]
		Outer root sheath cells (ORC)	In vitro	[34]
		C3H/NeH mice	In vivo	[31,34]
		C57BL/6 mice	In vivo	[33,35]
		Nude mice	In vivo	[32]
4.	Psoriasis	Wistar rats	In vivo	[36]
5	Other (antimicrobial)	Rats	In vivo	[37]