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. 2021 Oct 5;23(11):1110–1122. doi: 10.1016/j.neo.2021.09.003

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© 2021 The Authors. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 6 — RSI and iRIS are mutually related to improved outcomes in patients treated with radiation. (A) Tumors were separated into quadrants by RSI^lo and RSI^hi (population median RSI, 0.42), as well as iRIS^lo and iRIS^hi (population median iRIS, 3.61) and represented on the TIES map. (B) Tumor types were classified based on the proportion of patients in the most ‘favorable’ quadrant (e.g., iRIS^lo/RSI^lo). (C) Patient NSCLC tumors with dual RSI^lo/iRIS^lo phenotypes have improved OS (HR 0.38, 95% CI: 0.16–0.92; P < 0.01) compared to those with RSI^hi/iRIS^hi. (D) A RSI^lo phenotype with an unfavorable TIES (iRIS^hi) or vice versa, cannot compensate for the other (HR 1.1, 95% CI: 0.4–3.1; P = 0.84).