TABLE 5.

Hazard ratios of cardiovascular disease for the top 10 frequently used polyherbal formulas in comparison with the matched non-CHM groups.

Polyherbal formulas	Patients/total CHM users (%)	Adjusted HR (95%CI)
		Model 1	Model 2
Jia-Wei-Xiao-Yao-San	975/2,751 (35.4%)	0.87 (0.70–1.08)	0.91 (0.73–1.13)
Shao-Yao-Gan-Cao-Tang	636/2,751 (23.1%)	0.82 (0.63–1.05)	0.85 (0.66–1.10)
Ge-Gen-Tang	618/2,751 (22.5%)	0.77 (0.59–1.01)	0.80 (0.61–1.05)
Xiao-Chai-Hu-Tang	588/2,751 (21.4%)	0.79 (0.61–1.03)	0.82 (0.63–1.08)
Shu-Jing-Huo-Xue-Tang	585/2,751 (21.3%)	0.74 (0.57–0.96)*	0.76 (0.58–0.99)*
Zhi-Bo-Di-Huang-Wan	541/2,751 (19.7%)	0.83 (0.62–1.10)	0.89 (0.66–1.18)
Liu-Wei-Di-Huang-Wan	533/2,751 (19.4%)	0.79 (0.60–1.05)	0.83 (0.62–1.10)
Gan-Lu-Yin	529/2,751 (19.2%)	0.88 (0.67–1.16)	0.95 (0.72–1.25)
Ban-Xia-Xie-Xin-Tang	528/2,751 (19.2%)	0.80 (0.60–1.07)	0.80 (0.60–1.08)
Chuan-Qiong-Cha-Tiao-San	502/2,751 (18.3%)	0.74 (0.55–1.01)	0.78 (0.57–1.07)

Model 1: adjusted for age, gender, insured amount, and urbanization level.

Model 2: adjusted for age, gender, insured amount, urbanization level, comorbidities, and baseline drugs.

HR, hazard ratio; CHM, Chinese herbal medicine; CI, confidence interval.

*p-value < 0.05.