TABLE 2.

Prognostic value of the SOCS3 gene determined by multivariate Cox regression analysis in GBM.

Cohort	Variable	N	Events	Log-rank test (p-value)	HR unadjusted (95% CI)	HR adjusted (95% CI)
TCGA	SOCS3
	Low	75	56	0.03	1 (Reference)	1 (Reference)
	High	75	62		1.506 (1.037–2.817)	1.31 (0.9–1.92)
	IDH1
	Mutant	8	3	0.008	1 (Reference)	1 (Reference)
	Wild-type	139	113		4.667 (1.47–14.77)	4.1 (1.27–13.19)
TCGA325	SOCS3
	Low	43	34	0.023	1 (Reference)	1 (Reference)
	High	42	39		1.72 (1.08–2.74)	1.58 (0.95–2.62)
	IDH1
	Mutant	11	9	0.13	1 (Reference)	1 (Reference)
	Wild-type	74	64		1.72 (0.85–3.50)	1.35 (0.63–2.92)
TCGA693	SOCS3
	Low	68	50	0.03	1 (Reference)	1 (Reference)
	High	68	59		1.54 (1.04–2.21)	1.3 (0.86–1.93)
	IDH1
	Mutant	23	14	0.02	1 (Reference)	1 (Reference)
	Wild-type	106	91		1.98 (1.12–3.48)	1.79 (0.99–3.22)
GSE16011	SOCS3
	Low	79	74	0.06	1 (Reference)	1 (Reference)
	High	80	74		1.36 (0.98–1.88)	1.12 (0.77–1.62)
	IDH1
	Mutant	33	28	0.002	1 (Reference)	1 (Reference)
	Wild-type	95	90		2.04 (1.29–3.22)	2.0 (1.26–3.17)