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. 2021 Aug 31;297(4):101152. doi: 10.1016/j.jbc.2021.101152

Figure 5.

Figure 5

JNK2, but not JNK1, mediates LPA-induced TF expression. The specific JNK1 and JNK2 siRNAs (40 nM) were transfected into MASMCs for 48 h followed by serum starvation for 24 h; cells were then stimulated with 10 μM of LPA for 5 h. For each JNK isoform, two siRNAs targeting different sequences were utilized. A, effect of knockdown of the expression of JNK isoforms with the specific JNK1 or JNK2 siRNAs on LPA-induced TF expression. B, results were quantified by densitometry. Data are mean ± SD from three experiments. ∗∗p < 0.01 versus LPA-treated, nonsilencing siRNA group.