Figure 7.

LPA₁is responsible for LPA-induced PKD and MAPK phosphorylation and TF expression.A, wild type (WT), LPA₁-/- and LPA₂-/- MASMCs were stimulated with 10 μM of LPA for 5 min (kinase activation) or 5 h (TF expression). Phosphorylation of PKD, p38, JNK, and ERK, as well as TF expression, was examined by Western blot analysis. B, results were quantified by densitometry. Data are mean ± SD from three experiments. ∗∗p < 0.01 versus LPA-treated (WT group).