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. 2021 Sep 27;8:713824. doi: 10.3389/fmed.2021.713824

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Copyright © 2021 Chen, Chen, Lin, Chen, Wen, Hsiao, Chou, Chung and Chuang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) reduced neutrophils and increased lymphocytes in bronchoalveolar lavage fluid (BALF) of mice. (B) Regulation of cytokine production (tumor necrosis factor (TNF)-α, interleukin (IL)-1β, C-X-C motif chemokine ligand 1 (CXCL1)/keratinocyte chemoattractant (KC), and IL-17A) by hUC-MSCs in BALF. A significant decrease in neutrophils (%) was observed by hUC-MSC administration, whereas lymphocytes (%) increased after hUC-MSC administration. There was no significant difference in cytokine production in BALF after hUC-MSC administration. The results were determined by a one-way ANOVA with Tukey's test. n = 8–10 per group. ^***p < 0.001.