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. 2021 Sep 27;9:739358. doi: 10.3389/fcell.2021.739358

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Copyright © 2021 Dong, Wu, Huang and Qi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of mRNA modules associated with lymph node metastasis and M0 infiltration. Gene set enrichment analysis (GSEA) suggested that early lymph node metastasis was related to the inflammatory response (IR) pathway (A), and the epithelial–mesenchymal transition (EMT) pathway were significantly enriched in the M0 high-infiltration group (B). (C) The scale-free mRNA network was clustered into 13 modules by average hierarchical clustering and dynamic tree clipping. (D) The correlation heatmap was used to describe the relationship between 13 genesets and N stage, M0 infiltration. ES, enrichment score. NES, normalized ES. NOM p-val, normalized p-value. TOM, topological overlap matrix.