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. 2021 Sep 27;9:739358. doi: 10.3389/fcell.2021.739358

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Copyright © 2021 Dong, Wu, Huang and Qi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of long non-coding RNAs (lncRNAs) associated with early lymph node metastasis, SPP1 expression, and M0 infiltration. (A) Hierarchical clustering analysis was performed to determine the lncRNA co-expression modules represented by different colors. (B) The heatmap was used to demonstrate the correlation between the modules and lymph node metastasis, SPP1 expression, and M0 infiltration. (C–E) The top 10 hub lncRNAs and their first-level nodes of 3 key modules (“MEmagenta,” “MEred,” and “MEgreen”) were identified through the maximal clique centrality (MCC) algorithm (the color of the hub nodes represented the hub level, red is the highest, and followed by orange). (F) The correlation analysis of 30 hub lncRNAs with SPP1 expression and M0 infiltration is based on TCGA dataset. (G) Expression level analysis of lncRNA (AC037441) between the lymph node metastasis group and the non-metastatic group in TCGA cohort. *p < 0.05.