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. 2021 Sep 27;12:752546. doi: 10.3389/fendo.2021.752546

Table 1.

The different effects of NLRP3 inflammasome on bone cells.

Effector cells Effects Crosstalk pathways References
Osteoblasts Decreased cell migration ROS Liu SS et al. (43)
Inhibited the proliferation and differentiation of osteoblasts p-AKT and β-catenin Xu L et al. (49)
Osteoclasts Enhanced bone-resorption capacity of osteoclasts, but inhibited their efferocytosis ROS/MAPK/NF-κB pathway An Y et al. (50)
BMSCs Inhibits osteogenic differentiation and promotes adipogenic differentiation SIRT1 Wang L et al. (51)