Table 1.
The different effects of NLRP3 inflammasome on bone cells.
Effector cells | Effects | Crosstalk pathways | References |
---|---|---|---|
Osteoblasts | Decreased cell migration | ROS | Liu SS et al. (43) |
Inhibited the proliferation and differentiation of osteoblasts | p-AKT and β-catenin | Xu L et al. (49) | |
Osteoclasts | Enhanced bone-resorption capacity of osteoclasts, but inhibited their efferocytosis | ROS/MAPK/NF-κB pathway | An Y et al. (50) |
BMSCs | Inhibits osteogenic differentiation and promotes adipogenic differentiation | SIRT1 | Wang L et al. (51) |