. 2021 Sep 27;8:713652. doi: 10.3389/fcvm.2021.713652

Table 2.

Cox univariate and multivariate analysis for cardiovascular (a) and all-cause (b) mortality on the basis of eGFR strata.

	eGFR > 90						eGFR 60–90						eGFR < 60
	HR	*95% CI*	p	HR	*95% CI*	p	HR	*95% CI*	p	HR	*95% CI*	p	HR	*95% CI*	p	HR	*95% CI*	p
(A) CARDIOVASCULAR MORTALITY
Age, years				1.10	1.08–1.13	<0.001				1.11	1.11–1.12	<0.001				1.07	1.06–1.09	<0.001
Gender, male				1.64	1.13–2.28	0.009				1.04	0.91–1.19	0.539				1.51	1.23–1.85	<0.001
Uric acid, mg/dl	1.47	1.31–1.80	<0.001	1.21	1.08–1.36	0.001	1.13	1.08–1.19	<0.001	1.13	1.07–1.19	<0.001	1.10	1.03 −1.17	0.002	1.05	0.99–1.12	0.119
eGFR, ml/min per 1,73 m ²				0.97	0.94–1.01	0.150				0.99	0.99–1.00	0.094				0.98	0.97–0.99	<0.001
Diabetes, presence of				2.83	1.92–4.15	<0.001				1.84	1.59–2.14	<0.001				2.04	1.67–2.50	<0.001
Hypertension, presence of				1.29	0.88–1.89	0.199				1.12	0.95–1.32	0.179				1.94	1.47–2.57	<0.001
(B) ALL-CAUSE MORTALITY
Age, years				1.10	1.09–1.11	<0.001				1.10	1.09–1.10	<0.001				1.07	1.06–1.08	<0.001
Gender, male				1.37	1.10–1.70	0.004				1.15	1.05–1.27	0.004				1.63	1.41–1.90	<0.001
Uric acid, mg/dl	1.22	1.14–1.30	<0.001	1.15	1.07–1.23	<0.001	1.11	1.08–1.15	<0.001	1.11	1.07–1.47	<0.001	1.10	1.05–1.15	<0.001	1.05	1.00–1.10	0.050
eGFR, ml/min per 1,73 m ²				0.99	0.97–1.01	0.409				1.00	0.99–1.00	0.280				0.98	0.98–0.99	<0.001
Diabetes, presence of				1.93	1.49–2.49	<0.001				1.65	1.48–1.85	<0.001				1.99	1.71–2.32	<0.001
Hypertension, presence of				1.06	0.85–1.32	0.588				1.14	1.01–1.28	0.028				1.59	1.31–1.93	<0.001

HR, hazard ratio; CI, confidence interval; ACM, all-cause mortality; CVM, cardiovascular mortality; eGFR, estimated glomerular filtration rate (ml/min/1.73 m²).