. 2021 Sep 27;8:713652. doi: 10.3389/fcvm.2021.713652

Table 3.

Cox Multivariate Analysis for cardiovascular (a) and all-cause (b) mortality.

	Multivariate model 1			Multivariate model 1b			Multivariate model 2			Multivariate model 3
	HR	95% CI	p	HR	95% CI	p	HR	95% CI	p	HR	95% CI	p
(A) RISK FACTORS for CARDIOVASCULAR MORTALITY
Age, years	1.11	1.11–1.12	<0.001	1.11	1.10–1.11	<0.001	1.10	1.10–1.11	<0.001	1.10	1.09–1.12	<0.001
Gender, male	1.09	0.98–1.20	0.104	1.15	1.04–1.28	0.008	1.16	1.04–1.29	0.006	1.13	0.85–1.54	0.418
Uric acid, mg/dl	1.14	1.11–1.18	<0.001	1.12	1.08–1.16	<0.001	1.12	1.08–1.16	<0.001	1.21	1.09–1.34	<0.001
eGFR, ml/min per 1.73 m ²				0.99	0.99–0.99	0.002
eGFR, >90 ml/min per 1.73 m²							Ref
eGFR 90 – 60 ml/min per 1.73 m ²							1.30	1.08–1.56	0.005
eGFR <60 ml/min per 1.73 m²							1.33	1.07–1.65	0.009
Diabetes, presence of							1.99	1.77–2.23	<0.001	1.97	1.37–2.84	<0.001
Hypertension, presence of							1.33	1.17–1.52	<0.001	3.56	1.92–6.60	<0.001
Albuminuria, presence of										2.47	1.69–3.60	<0.001
(B) RISK FACTORS for ALL-CAUSE MORTALITY
Age, years	1.10	1.09–1.10	<0.001	1.10	1.09–1.10	<0.001	1.09	1.09–1.10	<0.001	1.08	1.07–1.09	<0.001
Gender, male	1.21	1.13–1.30	<0.001	1.24	1.15–1.34	<0.001	1.26	1.17–1.35	<0.001	1.01	0.82–1.25	0.901
Uric acid, mg/dl	1.11	1.09–1.14	<0.001	1.10	1.07–1.13	<0.001	1.10	1.07–1.13	<0.001	1.10	1.02–1.18	0.015
eGFR, ml/min per 1.73 m ²				0.99	0.99–1.00	0.087
eGFR, >90 ml/min per 1.73 m²							Ref
eGFR 90 – 60 ml/min per 1.73 m ²							1.02	0.91–1.14	0.762
eGFR <60 ml/min per 1.73 m²							1.04	0.90–1.19	0.600
Diabetes, presence of							1.78	1.64–1.94	<0.001	1.99	1.52–2.59	<0.001
Hypertension, presence of							1.24	1.13–1.35	<0.001	5.60	3.38–9.28	<0.001
Albuminuria, presence of										2.11	1.60–2.78	<0.001

HR, hazard ratio; CI, confidence interval; ACM, all-cause mortality; CVM, cardiovascular mortality; eGFR, estimated glomerular filtration rate; LDL, low-density lipoprotein.