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. 2021 Sep 27;9:722960. doi: 10.3389/fcell.2021.722960

FIGURE 6.

FIGURE 6

Suppression of SESN2 increases sensitivity to chemotherapy in vivo. NU/NU nude mice were subcutaneously injected with SESN2-knockdown or control 143B cells. After 7 days, the mice were intraperitoneally injected with Cis (20 μmol/L) until they were killed on day 28. Tumour volume was measured on day 28 (A) (n = 3). Tumour growth curves were measured from days 7 to 28 (B) (n = 3). Tumour weight was measured on day 28 (C) (n = 3). Immunofluorescence staining of TUNEL, SESN2 expression, LC3 expression, P62 expression, p-mTOR expression, Bcl-2 expression, PERK expression, CHOP expression and p-eIF2α expression after tumour sample injection (D) (n = 3, scale bar = 50 μm). The data are presented as the mean ± SD. *p < 0.05 vs. the Control shRNA + Cis group.