FIGURE 15.

Tumor growth curve of tumor-bearing mice after the first injection of PEG-b-P(L-Arg)/m (Kudo and Nagasaki, 2015). The number of injections was changed from 1 up to 4 times on days 0–3 at a dose of 16 mg/kg on an arginine basis. Injection times are 1 (closed circles), 2 (open triangles), 3 (closed triangles), and 4 (open lozenges). Tumor volume change of PBS-treated mice was also shown as open squares. (n = 4, expressed as mean ± S.E., *p < 0.05). Abbreviation: P(L-Arg), poly(L-Arginine); m, micelles.