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. 2021 Sep 27;9:744657. doi: 10.3389/fbioe.2021.744657

FIGURE 5.

FIGURE 5

Schematic illustration of the preparation of pH-responsive PIC micelle, and its circulation in vivo, accumulation in tumor tissue, and finally, pH-triggered intracellular DOX release after intravenous injection (Wang J. et al., 2015). Abbreviation: PEG, poly(ethylene glycol); PLL, poly(L-lysine); CDA, cis-cyclohexene-1,2-dicarboxylic anhydride; PCLL, poly(N(ε)-((1-carboxy-cis-cyclohexene)-2-carbonyl)-L-lysine; DOX, doxorubicin; PIC micelle, polyion complex micelle.