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. 2021 Sep 27;8:719982. doi: 10.3389/fmolb.2021.719982

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Copyright © 2021 Liu and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Subclass mapping analysis showed that cluster 2 is sensitive to CTLA4-R. [The Cancer Genome Atlas (TCGA): PCTLA4-R = 0.010; E-MTAB-1980: PCTLA4-R = 0.191; International Cancer Genome Consortium (ICGC): PCTLA4-R = 0.232] Based on corrected p-values, cluster 1 is not sensitive to CTLA4-R. (B) Box plot of estimated IC₅₀ values for sunitinib and doxorubicin in cluster 1 and cluster 2. [(A): TCGA; (B): E-MTAB-1980; (C): International Cancer Genome Consortium (ICGC)].