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. 2021 Sep 27;11:711735. doi: 10.3389/fonc.2021.711735

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Copyright © 2021 Liu, Guo, Qin and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of otubain 2 (OTUB2) and KDM1A in GC cells are positively correlated. (A) The expression of OTUB2, KDM1A, and CD44 was measured by immunohistochemistry in GC tissues collected from patients with GC. (B) The correlation between the expression of OTUB2, KDM1A, and CD44 in human tumor tissues was analyzed. (C) After OTUB2 was overexpressed (SGC-7901 cells) or downregulated (HGC-27 cells), the expression of KDM1A and CD44 was detected by immunohistochemistry in tumor tissues obtained from nude mice.