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. 2021 Sep 27;15:710481. doi: 10.3389/fncel.2021.710481

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Copyright © 2021 Qin, Peng, Zhong, Cai, Zhou, Chen, Zhuang, Zeng, Xu, Xu, Li, Ying, Gu, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pharmacological inhibition of microglial PAR-2 alleviated MCs-mediated inflammatory injury at 24 h after SAH. (A) Immunofluorescence staining demonstrates the expression of PAR-2 in sham and SAH mice. n = 6. Scale bar = 50 μm. (B–G) Representative western blotting images and quantitative analyses of tryptase, PAR-2, TNF-α, IL-1β, and IL-6 expression in ipsilateral basal cortex after SAH. (H) The quantification of brain water content. (I,J) The quantification of neurobehavioral test. n = 6. Data are represented as mean ± SD. *P < 0.05 versus SAH + vehicle group. #P < 0.05 versus SAH + compound 48/80 group.