Fig. 2.

Main effect of Age. Association between Age and directed subcortico-cortical influence or regional functional segregation (self-connections) in the whole group. An increase in age results in decreased influence (in blue) of subcortical over cortical sensory activity, and increased segregation (in orange) of the intrinsic activity of each region from that of other regions in the model. In the case of the ventral somatosensory cortex, age is associated with an increased top-down influence (in orange) on subcortical activity. Orange and blue connections represent interactions showing a significant effect of age (90% CI on DCM parameter estimates outside zero). The DCM parameter estimate for each significant connection is reported close to the corresponding arrow. SPM graphical outputs and results of this analysis before and after site correction are reported in Fig. S9. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)