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. 2021 Sep 27;11:748277. doi: 10.3389/fonc.2021.748277

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Copyright © 2021 Wang, Song, Hu, Wang, Jiang, Zhang, Yu, Han and Kan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD8⁺ TIL levels are decreased in mGBMs. (A) Typical MRIs of a unifocal GBM (uGBM), multifocal GBM, and multicentric GBM (mGBM). (B) Representative CD8⁺ TIL IHC images of uGBM and mGBM cases. Scale bar, 20 μm. (C) The concentration of CD8⁺ TILs was significantly lower in mGBMs than in uGBMs. (D) IHC staining of CD8⁺ TILs in different foci of multicentric and multifocal GBMs. Scale bar, 20 μm. (E) The presence of CD8⁺ TILs was similar between multifocal and multicentric GBMs. (F) In mGBMs, no significant difference in the concentration of CD8⁺ TILs was observed among foci from the same patient. (G) CD8⁺ TIL levels were significantly correlated with preoperative KPS.