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. 2021 Sep 27;12:720437. doi: 10.3389/fmicb.2021.720437

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Copyright © 2021 Zhugunissov, Zakarya, Khairullin, Orynbayev, Abduraimov, Kassenov, Sultankulova, Kerimbayev, Nurabayev, Myrzakhmetova, Nakhanov, Nurpeisova, Chervyakova, Assanzhanova, Burashev, Mambetaliyev, Azanbekova, Kopeyev, Kozhabergenov, Issabek, Tuyskanova and Kutumbetov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study design of QazCovid-in vaccination in Syrian hamsters. (A) The study of the safety of the inactivated QazCovid-in vaccine in Syrian hamsters. (B) The determination of immunogenicity and evaluation of the protective efficacy of the inactivated QazCovid-in vaccine in Syrian hamsters. PCR, polymerase chain reaction; VI, virus isolation; HPT, histopathology. Notes (#)—measurement of body temperature and body weight was carried out within 14 days. (s)—sampling of blood serum to determine the titer of viurs-neutralizing antibodies (*)—on 3, 5, 7, 9, 12, and 14 DPI, samples of nasal and oral swabs were collected and examined by PCR and viral isolation in cell culture.