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. 2021 Sep 27;12:720437. doi: 10.3389/fmicb.2021.720437

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Copyright © 2021 Zhugunissov, Zakarya, Khairullin, Orynbayev, Abduraimov, Kassenov, Sultankulova, Kerimbayev, Nurabayev, Myrzakhmetova, Nakhanov, Nurpeisova, Chervyakova, Assanzhanova, Burashev, Mambetaliyev, Azanbekova, Kopeyev, Kozhabergenov, Issabek, Tuyskanova and Kutumbetov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Performance indicators of the inactivated QazCovid-in. (A) Vaccine- virus neutralizing antibodies (VNA) in blood serum samples of Syrian hamsters before (day 0) and after vaccination. The graph shows the average values of VNA titers with standard deviation (mean ± SD). ^∗∗∗p < 0.001. (B) The survival rate of vaccinated and unvaccinated hamsters, after infection with the wild SARS-CoV-2 virus. (C) The temperature reaction of vaccinated and unvaccinated hamsters after challenge with wild homologous SARS-CoV-2 virus. There was no significant difference in average body temperature between the vaccinated and unvaccinated groups (p ≥ 0.05). (D) Changes in the body weight percentage of vaccinated and unvaccinated hamsters after challenge with the wild homologous SARS-CoV-2 virus; 42 indicates the vaccinated group challenged 42 days after vaccination, 6 indicates the vaccinated group challenged 6 months after vaccination. ns indicates no significance. ^#The first dose was inoculated on day 0. ^##The second dose was administrated on the 21st day.