TABLE 3.

NfPs and fragments as biomarkers in conditions affecting nervous system.

Conditions	Association of NF subunit level with						Association of NF subunit level with			References
	NfL	pNfH (smi35)			NfH (smi31 and others)
	B	C	B	C	B	C	Disease activity	Prognosis	Treatment response
Acute bacterial meningitis	+									Gronhoj et al., 2021
Anesthesia and surgery	+									Evered et al., 2018
Anorexia nervosa	+									Nilsson et al., 2019
Autoimmune encephalitis		+		+					yes	Kortvelyessy et al., 2018; Fominykh et al., 2019; Piepgras et al., 2021
Brain metastasis and glioma	+						yes	yes		Hepner et al., 2019
Cardiac arrest	+						yes	yes		Moseby-Knappe et al., 2019
Cerebral small vessel disease	+						yes	yes		Egle et al., 2021; Qu et al., 2021
Chemotherapy-induced cognitive impairment					+		yes			Natori et al., 2015
Chorea-acanthocytosis	+						yes			Peikert et al., 2020
Diabetic neuropathy					+					Qiao et al., 2015
Hypoxic-ischemic encephalopathy						+	yes			Douglas-Escobar et al., 2010
Idiopathic normal pressure hydrocephalus		+								Jeppsson et al., 2013
Intrapartum asphyxia	+						yes			Toorell et al., 2018
Mcleod syndrome	+									Peikert et al., 2020
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes	+						yes			Zheng et al., 2021
Mitochondrial encephalopathy		+					yes	yes		Sofou et al., 2019
MOG-Abs-associated disorders				+						Sara et al., 2021
Neurosarcoidosis	+	+								Byg et al., 2021
Peri/intraventricular hemorrhage	+	+					yes	yes		Goeral et al., 2021
Postoperative delirium	+									Casey et al., 2019
Preeclampsia	+						yes	yes		Evers et al., 2018
Preterm infants	+									Depoorter et al., 2018
Sepsis-associated encephalopathy	+						yes	yes		Ehler et al., 2019
Severe COVID-19	+									Sutter et al., 2021
Thoracolumbar intervertebral disk herniation					+		yes	yes		Nishida et al., 2014
Wilson’s disease	+						yes			Shribman et al., 2021
X-linked adrenoleukodystrophy	+						yes		yes	Weinhofer et al., 2021

B, blood; C, CSF.