Table 2.
Multivariable analysis of factors associated with CIR of the 320-patient primary cohort.
| Subdistribution hazard ratio (SHR) | 95% Confidence Interval | p-value | VIF | |
|---|---|---|---|---|
| Pre-MRD (Pos vs. Neg) | 1.98 | 1.16~3.36 | 0.012 | 1.366 |
| Disease status pre-HSCT (>CR1 vs. CR1) | 1.90 | 1.03~3.51 | 0.040 | 1.594 |
| TP53 mutation (Pos vs. Neg) | 3.47 | 1.68~7.15 | 0.001 | 1.260 |
| FLT3-ITD mutation (high ratio vs. Neg or low ratio) | 2.07 | 1.08~3.95 | 0.028 | 1.153 |
| Cytogenetic abnormality | ||||
| Favorable | 1.0* | 1.0* | ||
| Intermediate | 3.37 | 1.41~8.02 | 0.006 | 3.499 |
| Adverse | 3.48 | 1.27~9.53 | 0.015 | 4.027 |
＊indicates reference category; VIF, variance inflation factor; CR1, first complete remission; MRD, minimal residual disease; HSCT, hematopoietic stem cell transplantation; CIR, cumulative incidence of relapse.