. 2021 Oct 11;269(5):2513–2526. doi: 10.1007/s00415-021-10820-2

Table 4.

Change in EDSS for all patients with RRMS segregated by pre-HSCT EDSS and for SPMS segregated by MRI enhancement within the prior year

Patients	EDSS: pre-HSCT baseline	EDSS: 6 months	EDSS: 1 year	EDSS: 2 years	EDSS: 3 years	EDSS: 4 years	EDSS: 5 years
RRMS
RRMS ALL@ Mean, median, (range), STD, 1st Q, 3rd Q (number) Δ EDSS P value	3.87, 3.5 (1–8) @ 1.43, 3, 4 (n = 414)	2.70, 2.5 (0–7) 1.48, 2, 3.25 (n = 259) P < 0.001	2.51, 2 (0–7) 1.48, 1.5, 3 (n = 299) P < 0.001	2.50, 2 (0–7.5) 1.60, 1.5, 3 (n = 224) P < 0.001	2.41, 2 (0–7.5) 1.61, 1.5, 3 (n = 158) P < 0.001	2.33, 2 (0–7.5) 1.75, 1, 3 (n = 96) P < 0.001	2.19, 2 (0–6.5) 1.70, 1, 3 (n = 80) P < 0.001
RRMS Pre-HSCT EDSS 2–4 @
Mean, median, (range), STD, 1st Q, 3rd Q (number) Δ EDSS P value	3.14, 3 (1–4) @ 0.66, 2.5, 3.5 (n = 302)	2.17, 2 (0–4) 0.99, 2.5, 3.5 (n = 179) P < 0.001	2.03, 2 (0–6) 1.06, 1.5–2.5 (n = 14) P < 0.001	1.99, 2 (0–5.5) 1.15, 1.37, 2.5 (n = 160) P < 0.001	1.94, 2 (0–6) 1.15, 1, 2.5 (n = 114) P < 0.001	1.78, 1.5 (0–6.5) 1.18, 1, 2 (n = 63) P < 0.001	1.95, 1,5 (0–6.5) 1.65, 1, 2.5 (n = 58) P < 0.001
RRMS Pre-HSCT EDSS 4.5–6
Mean, median, (range), STD, 1st Q, 3rd Q (number) Δ EDSS P value	5.5, 5.75 (4.5–6) 0.58, 5, 6 (n = 74)	3.38, 3 (0–6.5) 1.52, 2.4, 4.5 (n = 56) P < 0.001	3,21, 3 (0–6.5) 1.54, 2.5, 4 (n = 57) P < 0.001	2.81, 2.5 (0–6.5) 1.34, 2, 3,4 (n = 38) P < 0.001	2.85, 2.5 (0–6.5) 1.59, 1.5, 3.75 (n = 27) P < 0.001	2.5, 2.25 (0–6) 1.84, 1.37, 4 (n = 20) P < 0.001	2.38, 2 (0–6) 1.73, 1, 3 (n = 13) P < 0.001
RRMS Pre-HSCT EDSS 6.5
Mean, median, (range), STD, 1st Q, 3rd Q (number) Δ EDSS P value	6.5, 6.5 6.5 0, 6.5, 6.5 (n = 30)	5.13, 6 (2.5–7) 1.43, 4, 6,5 (n = 19) P < 0.001	4.88, 5 (2.5–7) 1,41, 3.5, 6 (n = 22) P < 0.001	5.21, 6 (2.5–7.5) 1.54, 4, 6.5 (n = 21) P = 0.001	5.1, 6 (1–7.5) 1.91, 4.1, 6.3 (n-14) P = 0.02	4.88, 5.5 (0–5.5) 2.02, 4, 6 (n = 12) P = 0.01	3.37, 3.75 (0–6) 1.7, 2.8, 4 (n = 8) P < 0.001
RRMS Pre-HSCT EDSS 7–8
Mean, median, (range), STD, 1st Q, 3rd Q (number) Δ EDSS P value	7.13, 7 (7–8) 0.45, 7, 7.6 (n = 8)	5.5, 6 (4–6) 1.0, 5.5, 6 (n = 4) P = 0.05	4.6, 5 (3–6) 1.51, 3, 6 (n = 4) P = 0.05
SPMS
All SPMS
Mean, median, (range), STD, 1st Q, 3rd Q (number) Δ EDSS P value	5.09, 5.5 (3–8) 1.32, 3, 6 n = 93	4.71, 4.25 (1–8) 1.56, 3.5, 6 n = 54 P < 0.001	4.85, 5.25 (2–6.5) 1.39, 3.5, 6 n = 64 P = 0.04	4.88, 5.5 (1.5–7) 1.54, 3.5, 6.5 n = 45 P = 0.20	4.92, 6 (0–7) 1.77, 3, 6.5 n = 33 p = 0.27	4.72, 6 (1.5–7.5) 1.95, 3, 6.4 n = 22 p = 0.07	4.21, 4 (1.5–6.5) 1.95, 2.5, 6 N = 16 P = 0.21
naSPMS MRI gadolinium negative in prior year
Mean, median, (range), STD, ^{1st Q, 3rd Q} (number) Δ EDSS P value	4.92, 5 (3–7) 1.26, 3.6, 6 n = 58	4.56, 4 (1–8), 1.57, 3.5, 6 n = 33 p = 0.04	4.88, 5.25 (2–6.5) 1.37, 3.5, 6 n = 38 p = 0.54	5.13, 5.5 (3–7) 1.34, 4, 6.4 n = 26 p = 1.0	4.89, 6 (0–6.5) 1.79, 3.5, 6.26 n = 19 p = 0.74	4.54, 5 (1.5–7.5) 2.15, 2.5, 6 n = 11 p = 0.27	4.71, 6 (1.5–6.5) 2.13, 3.25, 6.25 n = 7 p = 0.75
aSPMS, MRI gadolinium positive in prior year
Mean, median, (range), STD, 1st Q, 3rd Q (number) Δ EDSS P value	5.37, 6 (3–8) 1.40, 4, 6.5 n = 35	4.95, 5.5 (2–7.5) 1.56. 3.5, 6.5 n = 21 P = 0.002	4.82, 5 (2–6.5) 1.44, 3.5, 6 n = 26 P = 0.001	4.55, 4 (1.5–6.5) 1.76, 3, 6.5 n = 19 P = 0.003	4.93, 6 (2.5–7) 1.8, 3.1, 6.5 n = 14 P = 0.02	4.9, 5.5 (2.5–7) 1.81, 3, 6.5 n = 14 p = 0.1	3.88, 3 (2.5–6.5) 1.83, 2.5, 6 n = 9 p = 0.03

Patients

EDSS: pre-HSCT baseline

EDSS: 6 months

EDSS: 1 year

EDSS: 2 years

EDSS: 3 years

EDSS: 4 years

EDSS: 5 years

RRMS

RRMS ALL@

Mean, median,

(range),

STD, 1st Q, 3rd Q

(number)

Δ EDSS P value

3.87, 3.5

(1–8) @

1.43, 3, 4

(n = 414)

2.70, 2.5

(0–7)

1.48, 2, 3.25

(n = 259)

P < 0.001

2.51, 2

(0–7)

1.48, 1.5, 3

(n = 299)

P < 0.001

2.50, 2

(0–7.5)

1.60, 1.5, 3

(n = 224)

P < 0.001

2.41, 2

(0–7.5)

1.61, 1.5, 3

(n = 158)

P < 0.001

2.33, 2

(0–7.5)

1.75, 1, 3

(n = 96)

P < 0.001

2.19, 2

(0–6.5)

1.70, 1, 3

(n = 80)

P < 0.001

RRMS Pre-HSCT EDSS 2–4 @

Mean, median,

(range),

STD, 1st Q, 3rd Q

(number)

Δ EDSS P value

3.14, 3

(1–4) @

0.66, 2.5, 3.5

(n = 302)

2.17, 2

(0–4)

0.99, 2.5, 3.5

(n = 179)

P < 0.001

2.03, 2

(0–6)

1.06, 1.5–2.5

(n = 14)

P < 0.001

1.99, 2

(0–5.5)

1.15, 1.37, 2.5

(n = 160)

P < 0.001

1.94, 2

(0–6)

1.15, 1, 2.5

(n = 114)

P < 0.001

1.78, 1.5

(0–6.5)

1.18, 1, 2

(n = 63)

P < 0.001

1.95, 1,5

(0–6.5)

1.65, 1, 2.5

(n = 58)

P < 0.001

RRMS Pre-HSCT EDSS 4.5–6

Mean, median,

(range),

STD, 1st Q, 3rd Q

(number)

Δ EDSS P value

5.5, 5.75

(4.5–6)

0.58, 5, 6

(n = 74)

3.38, 3

(0–6.5)

1.52, 2.4, 4.5

(n = 56)

P < 0.001

3,21, 3

(0–6.5)

1.54, 2.5, 4

(n = 57)

P < 0.001

2.81, 2.5

(0–6.5)

1.34, 2, 3,4

(n = 38)

P < 0.001

2.85, 2.5

(0–6.5)

1.59, 1.5, 3.75

(n = 27)

P < 0.001

2.5, 2.25

(0–6)

1.84, 1.37, 4

(n = 20)

P < 0.001

2.38, 2

(0–6)

1.73, 1, 3

(n = 13)

P < 0.001

RRMS Pre-HSCT EDSS 6.5

Mean, median,

(range),

STD, 1st Q, 3rd Q

(number)

Δ EDSS P value

6.5, 6.5

6.5

0, 6.5, 6.5

(n = 30)

5.13, 6

(2.5–7)

1.43, 4, 6,5

(n = 19)

P < 0.001

4.88, 5

(2.5–7)

1,41, 3.5, 6

(n = 22)

P < 0.001

5.21, 6

(2.5–7.5)

1.54, 4, 6.5

(n = 21)

P = 0.001

5.1, 6

(1–7.5)

1.91, 4.1, 6.3

(n-14)

P = 0.02

4.88, 5.5

(0–5.5)

2.02, 4, 6

(n = 12)

P = 0.01

3.37, 3.75

(0–6)

1.7, 2.8, 4

(n = 8)

P < 0.001

RRMS Pre-HSCT EDSS 7–8

Mean, median,

(range),

STD, 1st Q, 3rd Q

(number)

Δ EDSS P value

7.13, 7

(7–8)

0.45, 7, 7.6

(n = 8)

5.5, 6

(4–6)

1.0, 5.5, 6

(n = 4)

P = 0.05

4.6, 5

(3–6)

1.51, 3, 6

(n = 4)

P = 0.05

SPMS

All SPMS

Mean, median,

(range),

STD, 1st Q, 3rd Q

(number)

Δ EDSS P value

5.09, 5.5

(3–8)

1.32, 3, 6

n = 93

4.71, 4.25

(1–8)

1.56, 3.5, 6

n = 54

P < 0.001

4.85, 5.25

(2–6.5)

1.39, 3.5, 6

n = 64

P = 0.04

4.88, 5.5

(1.5–7)

1.54, 3.5, 6.5

n = 45

P = 0.20

4.92, 6

(0–7)

1.77, 3, 6.5

n = 33

p = 0.27

4.72, 6

(1.5–7.5) 1.95, 3, 6.4

n = 22

p = 0.07

4.21, 4

(1.5–6.5)

1.95, 2.5, 6

N = 16

P = 0.21

naSPMS MRI gadolinium negative in prior year

Mean, median,

(range),

STD, ^{1st Q, 3rd Q}

(number)

Δ EDSS P value

4.92, 5

(3–7)

1.26, 3.6, 6

n = 58

4.56, 4

(1–8),

1.57, 3.5, 6

n = 33

p = 0.04

4.88, 5.25

(2–6.5) 1.37, 3.5, 6

n = 38

p = 0.54

5.13, 5.5

(3–7)

1.34, 4, 6.4

n = 26

p = 1.0

4.89, 6

(0–6.5)

1.79, 3.5, 6.26

n = 19

p = 0.74

4.54, 5

(1.5–7.5) 2.15, 2.5, 6

n = 11

p = 0.27

4.71, 6

(1.5–6.5)

2.13, 3.25, 6.25

n = 7

p = 0.75

aSPMS, MRI gadolinium positive in prior year

Mean, median,

(range),

STD, 1st Q, 3rd Q

(number)

Δ EDSS P value

5.37, 6

(3–8)

1.40, 4, 6.5

n = 35

4.95, 5.5

(2–7.5) 1.56. 3.5, 6.5

n = 21

P = 0.002

4.82, 5

(2–6.5)

1.44, 3.5, 6

n = 26

P = 0.001

4.55, 4

(1.5–6.5) 1.76, 3, 6.5

n = 19

P = 0.003

4.93, 6

(2.5–7)

1.8, 3.1, 6.5

n = 14

P = 0.02

4.9, 5.5

(2.5–7) 1.81, 3, 6.5

n = 14

p = 0.1

3.88, 3

(2.5–6.5)

1.83, 2.5, 6

n = 9

p = 0.03

@ while awaiting HSCT a single patient improved to EDSS 1.0. Δ Change in mean EDSS from mean at baseline, 1st aSPMS active secondary progressive multiple sclerosis, Q first quartile, 3rd Q third quartile EDSS = expanded disability status scale, HSCT hematopoietic stem cell transplantation, naSPMS non-active secondary progressive multiple sclerosis, RRMS relapsing remitting multiple sclerosis, SPMS secondary progressive multiple sclerosis, STD standard deviation