Table 2.

A summary of the therapeutic properties of bacteriophage against infections caused by colistin-resistant Gram-negative bacteria

Author name	Year	Phage	Organism	Result	Ref.
Ebrahimi et al	2020	IsfAB78	Colistin-resistant MDR A. baumannii	IsfAB78 phage was able to significantly lyse culture and biofilm of MDR A. baumannii	[86]
Hao et al	2019	ɸNJS1	Colistin-resistant CRKP	Colistin-resistant CRKP was also shown to be more susceptible to ɸNJS1 phage compared to wild-type bacteria when grown in biofilms or moth larvae and during mammalian colon colonization	[87]
Shokri et al	2017	Psu1, Psu2, and Psu3	MDR, XDR and PDR isolates of colistin-resistant P. aeruginosa	Phage cocktails showed antibacterial activity and completely destroyed the bacterial cells	[88]
Abdelkader et al	2020	PMK34	PDR colistin-resistant A. baumannii	PDR colistin-resistant A. baumannii strains were susceptible to the PMK34 phage	[89]
Manohar et al	2019	myPSH2311, myPSH1235, and myPSH1140	Meropenem and colistin-resistant E. coli, K. pneumoniae, and Enterobacter spp.	There was a reduction in bacterial load and efficacy was observed against all bacteria	[90]
Blasco et al	2019	ElyA1 and ElyA2 endolysins [from phage Ab1051Φ and Ab1052Φ]	Colistin-resistant MDR P. aeruginosa, MDR A. baumannii, and carbapenemase-producing K. pneumoniae isolates	ElyA1 illustrated antibacterial activity and combination of colistin and ElyA1 decreased the MIC of colistin in all isolates	[93]
Bernasconi et al	2017	PYO, INTESTI, and Septaphage	MDR carbapenemase-producers, colistin-resistant E. coli and Proteus spp. isolates	Although Septaphage had no antibacterial activity, carbapenemase producers and colistin-resistant isolates were susceptible to PYO and INTESTI	[94]
Aslam et al	2019	AB‐PA01, AB‐PA01 m1, Navy phage cocktail1, and Navy phage cocktail2 for patient one, AB‐PA01 for patient two, and single lytic phage for patient three	Colistin-resistant MDR P. aeruginosa and B. dolosa	Phage therapy was well related to clinical recovery in lung transplant recipients with MDR Gram-negative bacterial infections	[95]
Vukotic et al	2020	vB_AbaM_ISTD and vB_AbaM_NOVI	Colistin-resistant A. baumannii	Two colistin-resistant isolates were also sensitive to both NOVI and ISTD phages	[96]
Schirmeier et al	2018	Artilysin Art-175	Colistin-resistant mcr-1-positive E. coli isolates	Art-175 showed a high antimicrobial activity against all mcr-1 colistin-resistant E. coli isolates and the number of bacteria was reduced	[97]
Defraine et al	2016	Artilysin Art-175	MDR colistin susceptible and resistant A. baumannii	Art-175 had high bactericidal properties against all isolates, even colistin-resistant isolates	[98]