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. 2021 Oct 1;22(6):816. doi: 10.3892/ol.2021.13077

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Copyright: © Xie et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Overexpression of miR-100 inhibits the proliferation, invasion and migration of breast cancer cells. (A) The Cell Counting Kit-8 assay demonstrated that overexpression of FOXA1 reversed the effects of overexpressing miR-100 on the proliferation of MDA-MB-231 cells. (B) The Transwell assay demonstrated that overexpression of FOXA1 reversed the effects of overexpressing miR-100 on the invasion of MDA-MB-231 cells. (C) The Transwell assay detected invasion of cells in each group. (D) The wound healing assay revealed that overexpression of FOXA1 reversed the effects of overexpressing miR-100 on the migration of MDA-MB-231 cells. (E) The wound healing assay detected the lateral migration of cells in each group. The wound healing assay revealed that overexpression of FOXA1 reversed the effects of overexpressing miR-100 on the migration of MDA-MB-231 cells. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. miR, microRNA; FOXA1, forkhead box A1; NC, negative control.