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SARDs and pan-antagonists inhibit androgen-dependent organs in rats. Male Sprague Dawley rats (100–120 g) were treated orally with vehicle or 20 mg/kg 26f for 13 d. Animals were sacrificed on the 14th day, and seminal vesicle weights were recorded. The inhibition of the seminal vesicle growth measured as loss of organ weight by 26f vs vehicle was statistically significant (p = 0.0031). N = 5/group.
