. Author manuscript; available in PMC: 2022 Feb 12.

Published in final edited form as: J Med Chem. 2021 Jul 16;64(15):11045–11062. doi: 10.1021/acs.jmedchem.1c00439

Table 3.

In Vitro Metabolic Stability for Selected Compounds in Mouse Liver Microsomes (MLMs)

	(DMPK) MLM^a
compound ID	T_1/2 (min)	CL_int (mL/min/mg)
11 ^b	1.15	208.8
12 ^b	12.11	57.26
13 ^b	77.96	0.89
19c	24.61	28.16
19e	26.51	41.58
26a	3.96	157.5
26b	17.93	38.66
26e	5.07	136.8
26f	265	2.67
26h	>360	~0
5 (enzalutamide)	10.04 h^c	86.3^d

Compounds were incubated together with mouse liver microsomes (MLMs) with cofactors for phases I and II provided, as described in the Experimental Section.

Reported previously using the same method as in the Experimental Section.^38,40

T_1/2 (h) after oral administration in humans as previously reported in ref 43.

CL (mL/h/kg) after oral administration in humans as previously reported.⁴³