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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Acta Neuropathol. 2020 Oct 24;141(1):1–24. doi: 10.1007/s00401-020-02235-6

Fig. 2. Autopsy diagnosis of B-ASC involves staining with hematoxylin and eosin (H&E).

Fig. 2.

The VCING collaborative group provided a consensus among experts describing criteria for defining B-ASC and for generating parameters that reflect different severity of the pathology. These diagnostic criteria are presented on the right side of the figure. In this study [183], which included evaluation of n=113 brains and sampling from many different brain areas, stained slides of the occipital cortex white matter produced moderately strong inter-rater reliability among different neuropathologists, and a robust association with cognitive impairment, i.e., B-ASC pathology was more often present in cases with dementia than those with normal cognitive status.