Table 3.
Clinical and pathological correlations in NACC Neuropathology v10 Dataset, stratified by age of death
| Brain arteriolosclerosis (B-ASC) | Association with history of myocardial infarction# (p-value) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| <80 years at death | >=80 years at death | Overall p-value | |||||||
| B-ASC: None or mild, n(%) | B-ASC: Moderate or severe n(%) | p-value* | B-ASC: None or mild n(%) | B-ASC: Moderate or severe n(%) | p-value* | ||||
| Cardiovascular risk factor by clinical history ** | |||||||||
| Diabetes | No | 303 (88.9) | 188 (85.8) | 0.35 | 300 (86.5) | 340 (85.4) | 0.77 | 0.31 | <0.0001 |
| Yes | 38 (11.1) | 31 (14.2) | 47 (13.5) | 58 (14.6) | |||||
| Hypertension | No | 276 (60.5) | 158 (51.6) | 0.018 | 183 (36.2) | 182 (32.2) | 0.19 | 0.0002 | <0.0001 |
| Yes | 180 (39.5) | 148 (48.4) | 322 (63.8) | 383 (67.8) | |||||
| Hypercholesterolemia | No | 149 (44.5) | 86 (39.6) | 0.30 | 126 (36.7) | 135 (34.1) | 0.50 | 0.11 | <0.0001 |
| Yes | 186 (55.5) | 131 (60.4) | 217 (63.3) | 261 (65.9) | |||||
| Body mass index (BMI) >= 30 | No | 215 (81.1) | 138 (73) | 0.053 | 273 (84.3) | 284 (84.5) | 1.0 | 0.32 | 0.75 |
| Yes | 50(18.9) | 51 (27) | 51 (15.7) | 52 (15.5) | |||||
| Cerebrovascular pathology ** | |||||||||
| Cerebral microinfarct(s), >0 | No | 470 (86.9) | 285 (83.3) | 0.17 | 480 (79.2) | 408 (61.4) | <0.0001 | <0.0001 | 0.082 |
| Yes | 71 (13.1) | 57 (16.7) | 126 (20.8) | 257 (38.6) | |||||
| Cerebral microbleed(s), >0 | No | 499 (97.1) | 314(93.5) | 0.018 | 579 (97.1) | 618 (93.6) | 0.0051 | 0.00015 | 0.66 |
| Yes | 15 (2.9) | 22 (6.5) | 17 (2.9) | 42 (6.4) | |||||
| Cerebral large or lacunar mfarct(s), >0 | No | 495 (91.5) | 299 (87.2) | 0.050 | 536 (88.7) | 497 (74.6) | <0.0001 | <0.0001 | 0.50 |
| Yes | 46 (8.5) | 44(12.8) | 68 (11.3) | 169 (25.4) | |||||
| White matter rarefaction (moderate/severe) | No | 405 (84.2) | 168 (53.5) | <0.0001 | 527 (92.8) | 348 (56.4) | <0.0001 | <0.0001 | 0.41 |
| Yes | 76(15.8) | 146 (46.5) | 41(7.2) | 269 (43.6) | |||||
| CAA (moderate/severe) | No | 369 (68.3) | 177 (51) | <0.0001 | 464 (76.6) | 390 (58.7) | <0.0001 | <0.0001 | 0.19 |
| Yes | 171 (31.7) | 170 (49) | 142 (23.4) | 274 (41.3) | |||||
| Neurodegenerative disease pathology ** | |||||||||
| LATE-NC, Stage >=2 | No | 283 (74.5) | 191 (71.8) | 0.51 | 268 (75.9) | 291 (64.2) | 0.00045 | 0.00077 | 0.97 |
| Yes | 97 (25.5) | 75 (28.2) | 85 (24.1) | 162 (35.8) | |||||
| Hippocampal sclerosis, Any | No | 480 (88.2) | 286 (81.9) | 0.012 | 526 (86.8) | 509 (76.3) | <0.0001 | <0.0001 | 0.54 |
| Yes | 64(11.8) | 63 (18.1) | 80 (13.2) | 158 (23.7) | |||||
| Alzheimer’s disease, Intermediate/Severe | No | 121 (22.2) | 64(18.3) | 0.19 | 182 (30) | 133 (19.9) | <0.0001 | 0.00015 | 0.43 |
| Yes | 423 (77.8) | 285 (81.7) | 424 (70) | 534 (80.1) | |||||
| Lewy body disease, Any | No | 289(53.1) | 176 (50.4) | 0.47 | 414(68.3) | 395 (59.2) | 0.00093 | 0.022 | 0.73 |
| Yes | 255 (46.9) | 173 (49.6) | 192 (31.7) | 272 (40.8) | |||||
*
Chi-square test, 2-tailed
**
Cardiovascular risk factors are by self-report at last exam; pathological features are autopsy results
#
Myocardial infarction indicates either remote or recent by clinical history