. Author manuscript; available in PMC: 2022 Mar 1.

Published in final edited form as: Mol Psychiatry. 2020 May 20;26(9):5040–5052. doi: 10.1038/s41380-020-0777-6

Table 2.

Associations of Chromosome 18 SNPs with maximum drinks consumed in a 24-hour period (maxdrinks) and DSM-5 AUD symptom count in COGA families

		Maxdrinks (EA, N: 7,289)		Maxdrinks (AA, N: 3,076)		AUD Severity (EA, N: 7,169)		AUD Severity (AA, N: 3,026)
SNP	A1	beta	p-value	beta	p-value	beta	p-value	beta	p-value
rs12954372	A	0.03	0.047	0.08	0.006	0.03	0.036	0.07	0.013
rs12965943	G	0.03	0.039	0.10	0.002^*	0.03	0.037	0.08	0.003^*
rs12957925	A	0.03	0.038	0.10	0.002^*	0.03	0.036	0.08	0.005
rs12455089	G	0.03	0.034	0.09	0.005	0.03	0.031	0.08	0.005
rs12456531	C	0.03	0.034	0.09	0.005	0.03	0.031	0.07	0.006
rs8088204	T	0.03	0.023	0.10	0.001^*	0.03	0.029	0.09	0.001^*

Withstands multiple test correction: 0.05/# of independent tests x four phenotypes= 0.01 for EAs and 0.005 for AAs. Note: Given the high LD observed among these six SNPs, p-values were adjusted for the number of tests (1.2 for EAs and 2.1 for AAs) as estimated using the p_norm procedure⁵³.