Table 3.
Associations of chromosome 18 SNPs with alcohol consumption measures in the UK 796 Biobank and alcohol dependence in the Psychiatric Genomics Consortium
| UK Biobank Alcohol Drinker Status: Never (EA, N: 337,000) |
UK Biobank Alcohol Use Frequency (EA, N: 337,000) |
PGC DSM-IV Alcohol Dependence (EA, N: 46,568) |
PGC DSM-IV Alcohol Dependence (AA, N: 6,280) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| SNP | A1 | beta | p-value | beta | p-value | OR | p-value | OR | p-value |
| rs12954372 | A | 0.0017 | 3.7e-4* | 0.015 | 2.7e-4* | 0.960 | 1.1E-01 | 0.937 | 4.3E-01 |
| rs12965943 | G | 0.0017 | 2.9e-4* | 0.015 | 2.1e-4* | 0.960 | 1.1E-01 | 0.890 | 6.3E-02 |
| rs12957925 | A | 0.0017 | 4.8e-4* | 0.015 | 2.4e-4* | 0.960 | 1.1E-01 | 0.908 | 1.2E-01 |
| rs12455089 | G | 0.0017 | 5.0e-4* | 0.015 | 1.9e-4* | 0.959 | 1.0E-01 | 0.942 | 3.2E-01 |
| rs12456531 | C | 0.0017 | 3.7e-4* | 0.015 | 1.4e-4* | 0.960 | 1.1E-01 | 0.940 | 3.1E-01 |
| rs8088204 | T | NA | NA | NA | NA | 0.961 | 1.2E-01 | 0.920 | 1.6E-01 |
Given the high LD observed among these six SNPs, p-values were adjusted for the number of tests (1.2 for EAs and 2.1 for AAs) as estimated using the pnorm procedure53. Associations of rs12965943 and rs8088204 survived multiple test-correction (0.05/# of independent tests x four phenotypes= 0.021 for EAs and 0.012 for AAs) for both phenotypes, and only among AA participants. Association of rs12957925 with maxdrinks among AA participants also survived a multiple test correction. All six SNPs were significantly (i.e., p<0.0001) associated with alcohol drinker status and alcohol intake frequency in the UK Biobank (Table 3). All associations withstood a multiple test correction; the minor allele was associated with increased AUD risk. None of the SNPs were significantly associated with DSM-IV AD in the PGC (Table 3).