Table 2.
Post-sequencing survey results stratified by receipt of fetal trio-ES results, receipt of medically actionable secondary finding, or receipt of no results.
| No trio-ES results reported | Fetal trio-ES results reported | Secondary findings reported | P value | |
|---|---|---|---|---|
|
| ||||
| N = 61 | N = 27 | N = 5 | ||
| HADS | ||||
| Anxiety subscale | 5.3 (3.7) | 6.9 (4.0) | 6 (3.7) | 0.17 |
| Depression subscale | 1.2 (2.5) | 3.2 (3.3) | 1.2 (2.7) | 0.003 |
| Total score | 6.5 (5.7) | 10.1 (6.5) | 7.2 (5.2) | 0.03 |
| N= 67 | N= 28 | N= 6 | ||
| MICRA | ||||
| Distress | 3.1 (5.2) | 8.1 (6.2) | 4.8 (4.9) | 0.0003 |
| Uncertainty | 5.2 (6.2) | 6.1 (4.7) | 5.7 (4.6) | 0.39 |
| Positive experience | 10.1 (4.3) | 9.6 (3.4) | 7.8 (4.5) | 0.28 |
| Total | 29.3 (16.5) | 36.3 (13.3) | 27.2 (18.1) | 0.02 |
| N= 61 | N= 27 | N= 5 | ||
| Decision Conflict Scale | 41.8 (5.5) | 43.2 (5.4) | 40 (0) | 0.34 |
| N= 61 | N= 24 | N= 6 | ||
| PAGIS | ||||
| Nonobtrusiveness | 4.5 (5.9) | 8.3 (5.8) | 8.7 (6.7) | 0.003 |
| Support | 3.7 (5.0) | 9.3 (9.2) | 7 (4.9) | 0.0007 |
| Certainty | 2.5 (4.0) | 1.9 (2.8) | 1.3 (1.6) | 0.92 |
| Total | 10.7 (12.3) | 19.4 (13.9) | 17 (10.2) | 0.001 |
ES exome sequencing, HADS Hospital Anxiety and Depression Scale, MICRA Multidimensional Impact of Cancer Risk Assessment, PAGIS Psychological Adaptation to Genetic Information Scale.
Data are presented as mean (SD) unless noted otherwise.
HADS is based on a scale of 0–21 with score >8 considered a positive screen. Anxiety and depression domains can be scored individually with scores >7 considered a positive screen. MICRA is a 25-question scale scored from 0 to 75 with subscales listed here. Decisional Conflict Scale (5-item) scored 13–17, >15 concerning for decisional conflict. PAGIS was adapted to an 18-item scale with subscales shown here.
Sample sizes for various surveys differ as subjects may have completed one survey but not another over course of study participation.