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. 2021 Oct 8;8(5):ENEURO.0062-21.2021. doi: 10.1523/ENEURO.0062-21.2021

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Copyright © 2021 Brown et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — A, Representative photomicrographs of Sox2⁺ NSCs and EdU⁺ proliferative cells in E19 dentate anlage. Blue DAPI stain denoted cell nuclei. IUGR offspring of both sexes showed decreased percentages of Sox2⁺ NSCs in the VZ and migratory stream (MS). p = 0.022, IUGR males compared with sex-matched sham controls; p = 0.005, IUGR females compared with sex-matched sham controls. By contrast, IUGR offspring of both sexes showed similar percentages of EdU⁺ proliferative cells in VZ and migratory stream. Dotted eclipses delineate the area of dentate anlage manually traced in ImageJ. B, Representative photomicrographs of Tbr2⁺ INPs in E19 dentate anlage. IUGR female offspring showed an increased percentage of Tbr2⁺ INPs in the MS and dentate anlage (p = 0.01, IUGR females compared with sham females). IUGR males had a percentage of Tbr2⁺ INPs similar to that of sham males. Two-way ANOVA with Tukey’s HSD post hoc test was used to examine the effects of treatment (sham or IUGR), sex, or both sex and treatment on the percentages of Sox2⁺, EdU⁺, or Tbr2⁺ cells.