Table 2.
Comparison of catastrophic AOSD patients and controls
| Catastrophic AOSD, n = 20 | Control AOSD, n = 41 | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | ||||||||
| p | p | Odds ratio | CI 95% | p | Odds ratio | CI 95% | |||
| Age | 33 (18–64) | 40.5 (18–79) | 0.01 | 0.013 | 0.94 | 0.9–0.98 | |||
| Male | 12 (60%) | 18 (44%) | 0.24 | ||||||
| Time from first symptoms to hospitalisation | 10 (1–61) | 20 (1–85) | 0.005 | 0.04 | 0.95 | 0.9–0.99 | |||
| Fever | 19 (95%) | 41 (100%) | 0.99 | ||||||
| Rash | 13 (65%) | 35 (85%) | 0.07 | ||||||
| Sore throat | 13 (65%) | 27 (66%) | 0.95 | ||||||
| Arthromyalgia | 17 (85%) | 37 (90%) | 0.377 | ||||||
| Arthralgia | 10 (50%) | 34 (83%) | 0.01 | 0.005 | 0.13 | 0.02–0.49 | 0.017 | 0.2 | 0.05–0.93 |
| Arthritis | 3 (15%) | 19 (46%) | 0.02 | ||||||
| Myalgia | 11 (55%) | 21 (52%) | 0.78 | ||||||
| Hepatomegaly | 11 (55%) | 13 (32%) | 0.08 | ||||||
| Splenomegaly | 9 (45%) | 8 (19%) | 0.04 | ||||||
| Adenopathy | 10 (50%) | 14 (34%) | 0.23 | ||||||
| Pleuritis | 5 (25%) | 7 (17%) | 0.47 | ||||||
| Pericarditis | 3 (15%) | 8 (19%) | 0.66 | ||||||
| Lung infiltrate | 7 (35%) | 2 (5%) | 0.006 | ||||||
| Myocarditis | 8 (40%) | 3 (7%) | 0.005 | ||||||
| Heart rate (/min) | 108 (73–150) | 95 (70–125) | 0.03 | ||||||
| Leukocytes (× 109/mL) | 16 (1–28) | 12 (2–35) | 0.11 | ||||||
| Haemoglobin (g/dL) | 12 (10–14) | 11 (9–14) | 0.95 | ||||||
| Platelets (× 109/mL) | 262 (142–521) | 271 (88–608) | 0.47 | ||||||
| Prothrombin time (%) | 70 (40–110) | 81 (39–123) | 0.23 | ||||||
| ASAT (UI/L) | 51 (14–615) | 51.5 (13–280) | 0.25 | ||||||
| ALAT (UI/L) | 34 (7–430) | 37.5 (6–433) | 0.65 | ||||||
| Creatinine (μmol/L) | 73 (46–274) | 71 (49–314) | 0.46 | ||||||
| CRP (mg/L) | 272 (61–495) | 151 (3–416) | 0.009 | ||||||
| Ferritin (ng/mL) | 27,153 (655–147,568) | 6680 (117–49,997) | 0.014 | ||||||
AOSD, adult-onset Still’s disease; ASAT, aspartate aminotransferase; ALAT, alanine aminotransferase; CRP, C-reactive protein; CI, confidence interval; frequency (%); median (min–max)
Variables included in the multivariate analysis: sex, age, age > 50 years, time from first symptoms to hospitalisation, rash, sore throat, arthralgia, arthromyalgia, arthritis, myalgia, hepatomegaly, splenomegaly, adenopathy, pleuritis, lung infiltrate, pericarditis, hepatitis, leukocytes, haemoglobin, platelets, CRP, ferritin and creatinine