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. 2021 Oct 10;12:537. doi: 10.1186/s13287-021-02590-5

Table 1.

Summary of fertility recovery study

H-CTR H-CH H-IV
Number of animals 7 8 8
Total number of pups 88.9 ± 20.6 24.5 ± 17.3 d 1 36.3 ± 19.2 d 1
Number of pups/litter (months 1–4) 14.5 ± 1.3 10.3 ± 2.1 a 1 9.5 ± 2.2 b 1
Number of litters 6.6 ± 1.1 2.3 ± 1.3 d 1 3.8 ± 1.3 c 1, * 2
Months of fertility from w-1 7.9 ± 1.2 2.4 ± 1.4 d 1 4.1 ± 1.7 c 1, * 2
Pregnancy rate (up to 1 litter) 100% (7/7) 100% (8/8) 100% (8/8)
Pregnancy rate (up to 2 litters) 100% (7/7) 62.5% (5/8) a 1 100% (8/8) * 1
Pregnancy rate (up to 3 litters) 100% (7/7) 37.5% (3/8) c 1 87.5% (7/8) ** 1
Pregnancy rate (up to 4 litters) 100% (7/7) 25% (2/8) d 1 50% (4/8) b 1
Pregnancy rate (up to 5 litters) 100% (7/7) 25% (2/8) d 1
Pregnancy rate (up to 6 litters) 85.7% (6/7) 12.5% (1/8) d 1
Pregnancy rate (up to 7 litters) 42.9% (3/7)
Pregnancy rate (up to 8 litters) 28.6% (2/7)
Pregnancy rate (up to 9 litters)

1Significance is calculated with One-way ANOVA vs CTR (letters) and vs CH (asterisks) as described in "Methods" section

2Significance is calculated with t-test vs CH (asterisks) as described in "Methods" section