Table 3.
Baseline comparability analysis results (ViV vsViR)
| Baseline | Studies | Effect measure | Model | Participants | Effect estimate | LCI | UCI | Q | P(Q) | Z | P(Z) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (years) | 4 | Mean difference | Fixed | 1862 | 2.48 | 1.23 | 3.72 | 3.93 | 0.27 | 3.90 | < 0.01 |
| Female | 5 | Odds ratio | Fixed | 2665 | 1.73 | 1.44 | 2.10 | 4.82 | 0.31 | 5.70 | < 0.01 |
| Diabetes mellitus | 5 | Odds Ratio | Fixed | 2599 | 0.85 | 0.69 | 1.07 | 4.20 | 0.38 | 1.40 | 0.16 |
| Hypertension | 2 | Odds ratio | Fixed | 538 | 1.10 | 0.73 | 1.65 | 0.91 | 0.34 | 0.45 | 0.65 |
| Atrial fibrillation | 4 | Odds ratio | Fixed | 2136 | 1.47 | 1.18 | 1.84 | 3.83 | 0.28 | 3.45 | < 0.01 |
| Chronic kidney disease | 3 | Odds ratio | Random | 2061 | 0.80 | 0.54 | 1.17 | 4.71 | 0.09 | 1.16 | 0.25 |
| Severe/chronic lung disease | 5 | Odds ratio | Fixed | 2599 | 1.00 | 0.81 | 1.24 | 2.70 | 0.61 | 0.01 | 0.99 |
| Peripheral arterial disease | 3 | Odds ratio | Fixed | 1353 | 0.84 | 0.60 | 1.18 | 0.41 | 0.82 | 1.01 | 0.31 |
| Prior cerebrovascular accident | 4 | Odds ratio | Fixed | 2420 | 1.59 | 1.19 | 2.13 | 0.57 | 0.90 | 3.12 | < 0.01 |
| Prior percutaneous coronary intervention | 1 | Odds ratio | Fixed | 463 | 0.63 | 0.38 | 1.03 | 0.00 | 1.00 | 1.85 | 0.06 |
| Prior pacemaker | 2 | Odds ratio | Random | 1879 | 0.76 | 0.29 | 2.03 | 13.03 | 0.00 | 0.54 | 0.59 |
| Prior aortic valve replacement | 2 | ||||||||||
| TAVR | 1 | Odds ratio | Fixed | 788 | 1.18 | 0.26 | 5.31 | 0.00 | 1.00 | 0.22 | 0.83 |
| SAVR | 2 | Odds ratio | Fixed | 960 | 1.15 | 0.74 | 1.78 | 0.00 | 0.99 | 0.62 | 0.54 |
| STS risk score (%) | 3 | Mean difference | Random | 630 | 4.88 | − 1.65 | 11.40 | 22.13 | 0.00 | 1.47 | 0.14 |
| Creatinine | 2 | Std. mean difference | Fixed | 538 | − 0.19 | − 0.38 | − 0.01 | 1.05 | 0.30 | 2.02 | 0.04 |
| Hemoglobin (g/dl) | 1 | Mean difference | Fixed | 75 | 0.60 | − 0.84 | 2.04 | 0.00 | 1.00 | 0.82 | 0.41 |
| NT-proBNP (ng/l) | 1 | Mean difference | Fixed | 75 | 1006 | − 1190 | 3202 | 0.00 | 1.00 | 0.90 | 0.37 |
| Echocardiographic parameters | 4 | ||||||||||
| LVEF, left ventricular ejection fraction (%) | 4 | Mean difference | Random | 1862 | 11.01 | 9.49 | 12.53 | 4.68 | 0.20 | 14.17 | < 0.01 |
| Right ventricular systolic pressure (mm Hg) | 1 | Mean difference | Random | 75 | 6.00 | − 6.32 | 18.32 | 0.00 | 1.00 | 0.95 | 0.34 |
| Mitral valve mean gradient (mmHg) | 3 | Mean difference | Random | 1787 | 4.14 | 3.25 | 5.03 | 4.33 | 0.11 | 9.09 | < 0.01 |
| PASP (mmHg) | 1 | Mean difference | Random | 1079 | 2.70 | 0.08 | 5.32 | 0.00 | 1.00 | 2.02 | 0.04 |
| MVA, mitral valve area (cm2) | 1 | Mean difference | Random | 1079 | − 0.46 | − 0.61 | − 0.31 | 0.00 | 1.00 | 5.86 | < 0.01 |
| Mode of prosthesis failure | 5 | ||||||||||
| Regurgitation | 5 | Odds ratio | Random | 2630 | 0.25 | 0.16 | 0.40 | 10.17 | 0.04 | 5.89 | < 0.01 |
| Stenosis | 5 | Odds ratio | Random | 2630 | 2.69 | 1.50 | 4.80 | 19.27 | 0.00 | 3.34 | < 0.01 |
| Combined | 4 | Odds ratio | Fixed | 1827 | 1.56 | 1.22 | 1.99 | 1.82 | 0.61 | 3.52 | < 0.01 |
| NYHA | 5 | ||||||||||
| I/II | 2 | Odds ratio | Random | 1882 | 1.30 | 0.43 | 3.92 | 6.32 | 0.01 | 0.46 | 0.64 |
| III/IV | 5 | Odds ratio | Random | 2588 | 1.31 | 0.25 | 6.78 | 22.37 | 0.00 | 0.32 | 0.75 |