Table 4.
Baseline comparability analysis results (ViMAC vs ViR)
| Baseline | Studies | Effect measure | Model | Participants | Effect estimate | LCI | UCI | Q | P(Q) | Z | P(Z) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (years) | 2 | Mean difference | Fixed | 226 | 3.78 | 0.91 | 6.66 | 1.17 | 0.28 | 2.58 | 0.01 |
| Female | 4 | Odds ratio | Random | 489 | 2.21 | 1.11 | 4.40 | 6.80 | 0.08 | 2.24 | 0.02 |
| Diabetes mellitus | 4 | Odds ratio | Fixed | 489 | 1.60 | 1.07 | 2.38 | 2.34 | 0.50 | 2.30 | 0.02 |
| Hypertension | 3 | Odds ratio | Fixed | 266 | 1.78 | 0.96 | 3.30 | 0.26 | 0.88 | 1.83 | 0.07 |
| Atrial fibrillation | 3 | Odds ratio | Fixed | 290 | 0.51 | 0.31 | 0.82 | 2.74 | 0.25 | 2.79 | 0.01 |
| Chronic kidney disease | 2 | Odds ratio | Fixed | 263 | 0.98 | 0.59 | 1.63 | 0.62 | 0.43 | 0.09 | 0.93 |
| Severe/chronic lung disease | 4 | Odds ratio | Random | 489 | 1.28 | 0.60 | 2.73 | 7.11 | 0.07 | 0.63 | 0.53 |
| Peripheral Arterial disease | 3 | Odds ratio | Fixed | 266 | 1.23 | 0.59 | 2.57 | 0.38 | 0.83 | 0.56 | 0.57 |
| Prior cerebrovascular accident | 4 | Odds ratio | Fixed | 489 | 1.24 | 0.74 | 2.06 | 5.46 | 0.14 | 0.81 | 0.42 |
| Prior percutaneous coronary intervention | 1 | Odds ratio | Fixed | 199 | 0.89 | 0.42 | 1.88 | 0.00 | 1.00 | 0.31 | 0.76 |
| Prior pacemaker | 1 | Odds ratio | Fixed | 223 | 0.98 | 0.53 | 1.81 | 0.00 | 0.00 | 0.07 | 0.95 |
| Prior aortic valve Replacement | 2 | ||||||||||
| TAVR | 2 | Odds ratio | Fixed | 260 | 9.74 | 2.54 | 37.36 | 0.05 | 0.82 | 3.32 | < 0.01 |
| SAVR | 2 | Odds ratio | Random | 262 | 1.11 | 0.19 | 6.45 | 5.40 | 0.02 | 0.11 | 0.91 |
| STS risk score, % | 2 | Mean difference | Fixed | 226 | 2.21 | 0.21 | 4.20 | 0.58 | 0.45 | 2.17 | 0.03 |
| Creatinine | 3 | Std. mean difference | Fixed | 266 | 0.06 | − 0.20 | 0.33 | 0.45 | 0.80 | 0.48 | 0.63 |
| Hemoglobin (g/dl) | 2 | Mean difference | Random | 67 | 0.06 | − 1.56 | 1.68 | 2.40 | 0.12 | 0.07 | 0.94 |
| NT-proBNP (ng/l) | 1 | Mean difference | Fixed | 27 | − 2919 | − 4825 | − 1013 | 0.00 | 1.00 | 3.00 | < 0.01 |
| Echocardiographic parameters | 3 | ||||||||||
| LVEF, left ventricular ejection fraction (%) | 3 | Mean difference | Fixed | 266 | 13.01 | 9.77 | 16.25 | 0.34 | 0.84 | 7.88 | < 0.01 |
| Mitral valve mean gradient (mmHg) | 1 | Mean difference | Fixed | 199 | 4.70 | 3.23 | 6.17 | 0.00 | 1.00 | 6.28 | < 0.01 |
| Right ventricular systolic pressure (mmHg) | 1 | Mean difference | Fixed | 27 | − 5.00 | − 19.40 | 9.40 | 0.00 | 1.00 | 0.68 | 0.50 |
| Mode of prosthesis failure | 4 | ||||||||||
| Regurgitation | 4 | Odds ratio | Fixed | 489 | 0.09 | 0.04 | 0.17 | 3.32 | 0.34 | 7.33 | < 0.01 |
| Stenosis | 3 | Odds ratio | Random | 449 | 7.38 | 1.79 | 30.43 | 13.54 | 0.00 | 2.77 | 0.01 |
| Combined | 2 | Odds ratio | Fixed | 226 | 1.82 | 0.90 | 3.69 | 0.67 | 0.41 | 1.60 | 0.10 |
| NYHA | 4 | ||||||||||
| I/II | 2 | Odds ratio | Fixed | 263 | 1.23 | 0.58 | 2.62 | 0.18 | 0.67 | 0.55 | 0.58 |
| III/IV | 4 | Odds ratio | Fixed | 489 | 1.02 | 0.56 | 1.84 | 0.48 | 0.79 | 0.06 | 0.95 |