Table 5.
The results of meta-analysis of postoperative outcomes (ViV vs ViR)
| Outcomes | Studies | Effect measure | Model | Participants | Effect estimate | LCI | UCI | Q | P(Q) | Z | P(Z) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| All-cause Mortality within 30 days | 5 | Odds ratio | Fixed | 2550 | 0.70 | 0.50 | 0.99 | 0.68 | 0.95 | 2.02 | 0.04 |
| Cardiovascular | 2 | Odds ratio | Fixed | 933 | 0.59 | 0.29 | 1.18 | 0.47 | 0.49 | 1.49 | 0.14 |
| Noncardiovascular | 1 | Odds ratio | Fixed | 688 | 0.67 | 0.24 | 1.82 | 0.00 | 1.00 | 0.79 | 0.43 |
| Unknown-cause | 4 | Odds ratio | Fixed | 1862 | 0.75 | 0.50 | 1.15 | 1.96 | 0.58 | 1.32 | 0.19 |
| Bleeding | 5 | Odds ratio | Random | 2665 | 0.68 | 0.13 | 3.61 | 73.19 | 0.00 | 0.45 | 0.65 |
| Major or extensive bleeding | 4 | Odds ratio | Random | 2420 | 1.66 | 0.98 | 2.80 | 3.11 | 0.38 | 1.89 | 0.06 |
| Life-threatening or fatal | 2 | Odds ratio | Random | 1266 | 0.44 | 0.25 | 0.77 | 0.48 | 0.49 | 2.85 | < 0.01 |
| Unknown | 1 | Odds ratio | Random | 245 | 14.47 | 0.85 | 245.08 | 0.00 | 0.00 | 1.85 | 0.06 |
| Embolization | 4 | Odds ratio | Fixed | 1577 | 0.34 | 0.12 | 0.98 | 3.57 | 0.31 | 2.00 | 0.045 |
| Conversion to Cardiac surgery | 3 | Odds ratio | Fixed | 1341 | 0.31 | 0.13 | 0.74 | 2.27 | 0.32 | 2.64 | 0.01 |
| Left ventricular outflow tract obstruction | 4 | Odds ratio | Fixed | 1586 | 0.22 | 0.11 | 0.44 | 3.07 | 0.38 | 4.31 | < 0.01 |
| Stroke | 4 | Odds ratio | Fixed | 2487 | 3.14 | 0.94 | 10.43 | 0.68 | 0.88 | 1.86 | 0.06 |
| Post-procedural echocardiographic findings | 4 | ||||||||||
| LVEF (%) | 3 | Mean difference | Fixed | 1347 | 8.74 | 7.03 | 10.46 | 0.20 | 0.91 | 10.00 | < 0.01 |
| Mitral valve mean gradient (mmHg) | 4 | Mean difference | Fixed | 1757 | − 0.46 | − 0.77 | − 0.15 | 2.39 | 0.50 | 2.88 | < 0.01 |
| Right ventricular systolic pressure (mmHg) | 1 | Mean difference | Fixed | 75 | 4.00 | − 5.05 | 13.05 | 0.00 | 1.00 | 0.87 | 0.39 |
| MVA, mitral valve area (cm2) | 3 | Mean difference | Fixed | 1617 | 0.03 | − 0.06 | 0.11 | 19.57 | 0.00 | 0.60 | 0.55 |
| Vascular complication | 4 | Odds ratio | Random | 2590 | 1.41 | 0.36 | 5.50 | 13.20 | 0.00 | 0.50 | 0.62 |
| Acute kidney injury | 3 | Odds ratio | Fixed | 1787 | 0.60 | 0.41 | 0.87 | 0.70 | 0.70 | 2.72 | 0.01 |
| Need for second valve implantation | 4 | Odds ratio | Fixed | 2420 | 0.21 | 0.14 | 0.33 | 0.70 | 0.87 | 7.13 | < 0.01 |
| Postprocedural mitral regurgitation | 3 | ||||||||||
| Trace/none | 3 | Odds ratio | Fixed | 2094 | 3.16 | 2.16 | 4.63 | 4.83 | 0.09 | 5.93 | < 0.01 |
| 1 (+) | 3 | Odds ratio | Fixed | 2094 | 0.44 | 0.28 | 0.70 | 6.17 | 0.05 | 3.47 | < 0.01 |
| 2 (+) or greater | 3 | Odds ratio | Fixed | 2094 | 0.27 | 0.13 | 0.59 | 4.23 | 0.12 | 3.28 | < 0.01 |