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. 2021 Oct 10;13:157. doi: 10.1186/s13073-021-00967-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Colocalization of rs2270401 with ERBB2 expression and DNA methylation levels for cg10374813. A LocusZoom plots of childhood onset GWAS results at the 17q locus showing the ERBB2 gene at the proximal (left) end of the locus and the co-localized eQTL (rs2270401) at the distal (right) end of the locus. The SNP (rs2270401), which colocalized with associations for childhood onset asthma, ERBB2 expression, and DNA methylation at cg10374813, is shown as a purple diamond in each of three LocusZoom plot. Upper panel: childhood onset asthma GWAS (modified from Pividori et al. 2019). Middle panel: ERBB2 eQTLs for vehicle-treated cultured AECs. The association for ERBB2 gene expression and rs2270401 for the vehicle treatment is shown in the box plot (β = − 1.16 × 10⁻³; 95% CI − 6.40 × 10⁻³, − 8.73 × 10⁻³). Lower panel: ERBB2 eQTLs for RV-treated AECs. Boxplots for ERBB2 gene expression by rs2270401 genotype is shown within the middle and lower LocusZoom plots. The association of ERBB2 gene expression and rs2270401 for the RV treatment is shown in the box plot (β = 0.03; 95% CI 0.04, 0.02). B Boxplots for cg1037813 meQTLs in vehicle-treated (upper panel; β = − 0.07; 95% CI − 0.07, − 0.09) and RV-treated (lower panel; β = − 0.10; 95% CI − 0.07, − 0.12) cultured AECs. C ERBB2 gene expression in vehicle-treated and RV-treated cells. P values and FDR adjusted P values (P_adj) are shown in each box plot