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. 2021 Oct 10;13:157. doi: 10.1186/s13073-021-00967-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — pcHi-C Interactions with ERBB2 and MED24 from ex vivo bronchial epithelial cells. pcHi-C interaction map indicating chromatin interactions (green arcs) between ERBB2 and MED24. The looping is occurring between the MED24 gene and the ERBB2 promoters. Solid green vertical lines indicate the SNPs associated with the co-localized triplet from the childhood onset asthma (rs2270401) and TAGC (rs2302774) GWASs. The dashed vertical line shows the location of the CpG associated with this triplet. A Capture Hi-C Analysis of Genomic Organisation (CHiCAGO) score ≥ 5 was considered as evidence for chromatin interactions (range for the four loops: 5.02–7.02)