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. 2021 Oct 11;14:149. doi: 10.1186/s13041-021-00851-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Comparison of synaptophysin and postsynaptic marker expression in hiPSC-NPC-derived neurons on day 49 and human adult brain tissue samples. Dot plots and boxplots showing the gene expression (ΔCt value) on day 49 in hiPSC-derived neurons (1210B2 and 1201C1, both with and without NGF) and adult human brain tissue samples (cerebellum and cerebrum). a Presynaptic marker, synaptophysin. b Presynaptic marker, Synapsin I. c Postsynaptic marker, drebrin A per drebrinA+E. d Postsynaptic marker, PSD-95. Statistical analysis was performed using ANOVA with the post hoc Tukey–Kramer method (***p < 0.001, **p < 0.01, *p < 0.05)